Griffith University

Aaron Lock

Name: Aaron Lock
Position: Research Assistant
Research Area: CTx
Qualifications: B. App. Sci (Lab Medicine) (Hons)

Biography: As a member of the CTx initiative, Aaron is involved in the development and optimisation of a range of isolated target molecule- and cell-based in vitro bioassays relating to specific cancer types. These bioassays are used to screen a library of >250, 000 drug-like compounds in order to identify potential cancer therapeutics. Following on from this, Aaron also investigates downstream targets for specific cancer signalling pathways, as a means of identifying drug inhibitor modes of action.

Discovery Biology

Publications:

Kaemmerer E, Rodriguez Garzon T, Lock A, Lovitt C and Avery VM. Innovative in vitro models for breast cancer drug discovery. Drug Discovery Today: Disease Models. [Invited review] 2017 March 18 [Epub ahead of print] 10.1016/j.ddmod.2017.02.002.

Stevenson G, Yong S, Fechner G, Neve J, Lock A and Avery VM. Solid-Phase Synthesis of Biotin-S-Farnesyl-L-Cysteine, a surrogate substrate for Isoprenylcysteine Carboxylmethyltransferase (ICMT). Bioorg Medicinal Chemistry Letters. 2013 Oct 15; 23(20): 5671-5673.

Conferences:

Brisbane Cell and Developmental Biology Meeting (Brisbane, Australia, 2014)

25th Lorne Cancer Conference (Lorne, Australia, 2013) Poster: Small molecule inhibitors of ICMT as potential cancer therapeutics.

24th Lorne Cancer Conference (Lorne, Australia, 2012)

Awards:

Griffith University Research Health and Safety Initiative Award (2013)