Griffith University

Catalina Carrasco

Name: Catalina Carrasco
Position: Research Fellow
Research Area: Cancer
Qualifications: Pharmaceutical Chemist (BSc (Hons), Pharmacology, PhD

Biography: Catalina graduated in 2005 as a Pharmaceutical Chemist (equivalent to BSc. Hons) from the University of Chile, Chile. In 2010, Catalina completed her PhD in Pharmacology at the University of Chile, Chile and was awarded a Postdoctoral Research Fellow (Fondecyt, Chile) for 3 years. She developed her postdoctoral research in the Faculty of Medicine, University of Chile, Chile; INRA/AgroParisTech, France and The University of Queensland, Australia. Since 2013 to 2017, Catalina held an academic position of Assistant Professor at the University of Chile and as Visiting Academic at The University of Queensland. During this period her research focus included oxidative stress, mitochondrial dysfunction, bioenergetics, inflammation, apoptosis and cell viability. Catalina joined the Discovery Biology team in April 2017 as part of the Cancer Therapeutics CRC team.

Other: University of Chile & University of Queensland

Publications:

Carrasco-Pozo C*, Tan KN, Gotteland M, Borges K. Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Cellular Longevity. Accepted 2017. doi: 10.1155/2017/3839756

Cires MJ, Wong X, Carrasco-Pozo C*, Gotteland M. The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins. Frontiers in Nutrition. 2017, 3:57

McDonald T, Carrasco-Pozo C, Hodson M, Borges K. Impaired glucose handling and TCA cycle enzyme activities reduce glucose metabolism in a chronic epilepsy mouse model. eNeuro. 2017, 4.

Carrasco-Pozo C*, Tan K.N, Reyes-Farias M, de la Jara N, Ngo S.T, Garcia-Diaz D.F, Llanos P, Cires M.J, Borges K. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies. Redox Biology. 2016, 9:229-243.

Wong X, Madrid A.M, Tralma K, Castillo R, Carrasco-Pozo C, Navarrete P, Beltran C, Pastene E, Gotteland M. Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers. Journal of Functional Foods. 2016, 26:406-17.

Tan K.N1, Carrasco-Pozo C1, McDonald T, Puchowicz M, Borges K. Tridecanoin is anticonvulsant, antioxidant and improves mitochondrial function. Journal of Cerebral Blood Flow & Metabolism. 2016 [Epub ahead of print]. 1These authors contributed equally to this work.

Farías J.G, Herrera E.A, Carrasco-Pozo C, Sotomayor-Zárate R, Cruz G, Morales P, Castillo R.L. Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress. Pharmacology & Therapeutics. 2016,158:1-23.

Carrasco-Pozo C*, Castillo RL, Beltrán C, Miranda A, Fuentes J, Gotteland M. Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2. Journal of Nutritional Biochemistry. 2016. 27:289-98.

Farías JG, Carrasco-Pozo C, Sepúlveda N, Álvarez P, Quezada M, Quiñones J,  Short SE, Castillo RL. PUFA induces cardioprotection through the inhibition of NF-kappaB and induction of Nrf2. Experimental Biology and Medicine. 2016. 58:1-23.

Morales P, Fujio S, Navarrete P, Ugalde JA, Magne F, Carrasco-Pozo C, Tralma K, Quezada M, Hurtado C, Covarrubias N, Brignardello J, Henriquez D, Gotteland M. Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers. Clinical and Translational Gastroenterology. 2016. 7:e161.

Wong X, Carrasco-Pozo C, Escobar E, Navarrete P, Blachier F, Andriamihaja M, Lan A, Cires MJ, Pastene E, Gotteland M. The deleterious effect of p-cresol on human colonic epithelial cells is prevented by proanthocyanidin-rich extracts from fruit and proanthocyanidin bacterial metabolites. Journal of Agricultural and Food Chemistry. 2016. 64:3574-83.

Carrasco-Pozo C, Tan K.N, Borges K. Sulforaphane is anticonvulsant and improves mitochondrial function. Journal of Neurochemistry. 2015.135:932-42.

Carrasco-Pozo C*, Gotteland M, Castillo R.L., Chen C. 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Experimental Cell Research. 2015. 334:270-82.

Andriamihaja M, Lan A, Beaumont M, Audebert M, Wong X, Yamada K, Yin Y, Tomé D, Carrasco-Pozo C, Gotteland M, Kong X, Blachier F. The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells. Free Radical Biology and Medicine 2015. 85:219-227.

Vergara D, Avila D, Escobar E, Carrasco-Pozo C, Sanchez A, Gotteland M. The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers – an explorative study. Nutrition Journal. 2015. 14:27.

Herrera EA, Farías JG, González-Candia A, Short SE, Carrasco-Pozo C, Castillo RL. Ω3 supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats. Marine Drugs. 2015: 13:838-60.

Gotteland M, Cires MJ, Carvallo C, Vega N, Ramirez MA, Morales P. Rivas P, Astudillo F, Navarrete P, Dubos C, Figueroa A, Troncoso M, Ulloa C, Mizgier ML, Carrasco-Pozo C, Speisky H, Brunser O, Figueroa G. Probiotic screening and safety evaluation of Lactobacillus strains from plants, artisanal goat cheese and human stool and milk. Journal of Medicinal Foods. 2014. 17:487-95.

Carrasco-Pozo C*, Morales P, Gotteland M. Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression. Journal of Agricultural and Food Chemistry. 2013. 61:5291-7.

Carrasco-Pozo C*, Pastene E, Vergara C, Zapata M, Sandoval C, Gotteland M. Stimulation of cytosolic and mitochondrial calcium mobilization by Indomethacin in Caco-2 cells: Modulation by the polyphenols quercetin, resveratrol and rutin. Biochimica et Biophysica Acta-General Subject. 2012. 1820:2052-61.

Carrasco-Pozo C*, Mizgier ML, Gotteland M, Speisky H. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chemico-Biological Interactions. 2012. 195:199-205.

Carrasco-Pozo C*, Gotteland M, Speisky H. Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition. Journal of Agricultural and Food Chemistry. 2011. 59:11501–11508.

Carrasco-Pozo C*, Speisky H, Brunser O, Pastene E, Gotteland M. Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats. Journal of Agricultural and Food Chemistry. 2011, 59:6459-66.

Aliaga ME, Carrasco-Pozo C, López-Alarcón C, Olea-Azar C, Speisky H. Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)-[GSH]2 complex. Bioorganic & Medicinal Chemistry. 2011, 19: 534–541.

Carrasco-Pozo C*, Gotteland M, Speisky H. Protection by apple peel polyphenols against indomethacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells. Journal of Pharmacy and Pharmacology. 2010, 62: 943–950.

Aliaga ME, Carrasco-Pozo C, López-Alarcón C, Speisky H. The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species. Transition Metal Chemistry. 2010, 35: 321-329.

Rodriguez J, Arán VJ, Boiani L, Olea-Azar C, Lavaggi ML, González M, Cerecetto H, Maya JD, Carrasco-Pozo C, Speisky H. New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies. Bioorganic & Medicinal Chemistry. 2009, 17:8186-8196.

Speisky H, Gómez M, Carrasco-Pozo C, Pastene E, Lopez-Alarcón C, Olea-Azar C. Cu(I)-Glutathione complex: a potential source of superoxide radicals generation. Bioorganic & Medicinal Chemistry. 2008, 16: 6568-6574.

Carrasco-Pozo C*, Aliaga ME, Olea-Azar C, Speisky H. Double edge redox-impliations for the interaction between endogenous tiols and copper ions: In vitro studies. Bioorganic & Medicinal Chemistry. 2008, 16:9795–9803.

O’Brien P, Carrasco-Pozo C, Speisky H. Boldine and its antioxidant or health-promoting properties. Chemico-Biological Interaction. 2006, 159:1-17.

Carrasco-Pozo C*, Alvarez-Lueje A, Olea-Azar C, López-Alarcón C, Speisky H. In vitro interaction between homocysteine and copper ions: Potential redox implications. Experimental Biology and Medicine (Maywood). 2006, 231:1569-1575.

Speisky H, Rocco C, Carrasco C, Lissi EA, López-Alarcón C. Antioxidant screening of medicinal herbal teas. Phytotherapy Research. 2006, 20:462-467.

López-Alarcón C, Rocco C, Lissi E, Carrasco C, Squella JA, Nuñez-Vergara L, Speisky H. Reaction of 5-aminosalicylic acid with peroxyl radicals: protection and recovery by ascorbic acid and amino acids. Pharmaceutical Research. 2005, 22:1642-1648.

Editorials:

Carrasco-Pozo C, PhD., Chapter: “Section 1 C: Polyphenol actions as enzyme modulators in health: Protection by polyphenols against mitochondrial damage and cytotoxicity” from the book entitled  “Polyphenols in Health and Disease”, Editors: Professor Ronald Ross Watson PhD, Professor Victor R. Preedy PhD DSc FRIPH, Sherma Zibadi, MD, PhD. Publisher: Academic Press, Elsevier. USA, UK. 2014.

Carrasco-Pozo C, Mizgier ML. Chapter: “Intestinal absorption and metabolism of dietary polyphenols and Vitamin C” from the book entitled “Gastrointestinal Physiology and Nutrition”, Editors: Oscar Brunser MD, Sylvia Cruchet MD and Martin Gotteland PhD. Publisher: NestléChile SA. 2013.

Grants and Awards:   

FONDECYT INITIATON INTO RESEARCH N° 11130232, CHILE (2013 – 2017) “Molecular and cellular basis of the protective effect of quercetin and its microbial metabolite 3,4-dihydroxyphenylacetic acid against the pancreatic β-cell dysfunction induced by cholesterol. In vitro and in vivo studies”. Role: Director USD 170,000

SOCHINUT/NESTLE-GRANT, CHILE (2016-2017) “Absorption of polyphenols; effect of hypolactasia and administration of exogenous lactase, a clinical study”. Role: Director USD 6,000

UNIVERSITY RESEARCH AWARD 2015 “UNIVERSIA SANTANDER” YOUNG RESEARCH TEAM CATEGORY, CHILE. “Cardioprotection by omega3 fatty acid in cardiovascular pathologies in animal and human models: from the Acute Myocardial Infarction to the Intermittent hypobaric hypoxia” USD 30,000

ECOS/CONICYT (France-Chile collaboration) (2013-2016) “Protective effects of proanthocyanidins and of their bacterial metabolites on human colonic epithelial cells exposed to H2S and p-cresol”. Role: Associate Investigator USD 14,000

FONDECYT REGULAR COMPETITION N°1120290, CHILE (2012-2016) “Reduction of fat absorption, and low grade endotoxinemia Inflammation by dietary proanthocyanidins as a strategy for the prevention of metabolic syndrome and its complications – An in vitro, animal and human study”. Role: Associate Investigator USD 300,000

FONDECYT POSTDOCTORATE N° 3110177, CHILE (2010-2013) “Evaluation of the gastro-protective effect of dietary polyphenols against mitochondrial, cellular, inflammatory and functional damage induced by indomethacin in the gastrointestinal tract”. Role: Director USD 90,000