Griffith University

Catalina Carrasco Pozo

Name: Catalina Carrasco Pozo
Position: Research Fellow
Research Area: Cancer
Qualifications: Pharmaceutical Chemist (BSc (Hons), Pharmacology, PhD

Biography: Catalina graduated in 2005 as a Pharmaceutical Chemist (equivalent to BSc. Hons) from the University of Chile, Chile. In 2010, Catalina completed her PhD in Pharmacology at the University of Chile, Chile and was awarded a Postdoctoral Research Fellow (Fondecyt, Chile) for 3 years. She developed her postdoctoral research in the Faculty of Medicine, University of Chile, Chile; INRA/AgroParisTech, France and The University of Queensland, Australia. Since 2013 to 2017, Catalina held an academic position of Assistant Professor at the University of Chile and as Visiting Academic at The University of Queensland. During this period her research focus included oxidative stress, mitochondrial dysfunction, bioenergetics, inflammation, apoptosis and cell viability. Catalina joined the Discovery Biology team in April 2017 as part of the Cancer Therapeutics CRC team.

Discovery Biology:

Prizes, Awards, Recognition, Scholarships:

  • 2018. Acceptance and completion: Bridge Program, Australia
  • 2018. Bursary Award Bridge Program. Australia from Queensland University of Technology, MTPConnect Project Fund Program, Australia
  • 2018. Funding support for Bridge Program, Australia from GRIDD, Griffith University, Australia
  • 2018. ECR Griffith Travel Grant, from GRIDD, Griffith University, Australia
  • 2018. ECR Griffith Travel Grant, from Griffith University, Australia
  • 2018. CTx Travel support, Australia
  • 2018. CTx Recognition award. As an integral member of the CTx drug discovery project team, I received a recognition award for my contribution to CTx securing an AUD$668M deal with Pfizer in October 2018 (AUD$20M upfront payment with up to a potential AUD$648M in development and sales milestones, as well as royalties if the program reaches commercialization)

Other: University of Chile & University of Queensland

Publications:

*corresponding author

Carrasco-Pozo C*. Cires MJ, Gotteland G. Quercetin and epigallocatechingallate in the prevention and treatment of obesity: from molecular to clinical studies. Journal of Medicinal Food. 2019. May 14. doi: 10.1089/jmf.2018.0193

Gonzalez-Candia A, Veliz M, Carrasco-Pozo C, Castillo RL, Cárdenas C, Ebensperger G, Reyes RV, Llanos AJ. Herrera EA. Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep. Redox Biology. 2019; 22.

Tan KN, Hood R, Warren K, Pepperall D, Carrasco-Pozo C, Manzanero S, Borges K, Spratt NJ. Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. Neuroscience Letters. 2018; 683:207-214. IF:2.159

Andriamihaja M, Lan A, Beaumont M, Grauso M, Gotteland M, Pastene E, Cires MJ, Carrasco-Pozo C, Tomé D, Blachier F. Proanthocyanidin-containing polyphenol extracts from fruits prevent the inhibitory effect of hydrogen sulfide on human colonocyte oxygen consumption. Amino Acids. 2018; 50:755-763. IF:3.173

Castillo RL, Herrera EA, Gonzalez-Candia A, Reyes-Farías M, de la Jara N, Peña JP, Carrasco-Pozo C*. Quercetin prevents diastolic dysfunction induced by a high cholesterol diet: role of oxidative stress and bioenergetics in hyperglycemic rats. Oxidative Medicine and Cellular Longevity. 2018; 2018:7239123. IF: 4.936

Tan KN, Simmons D1, Carrasco-Pozo C1, Borges K1. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry. 2018; 144:431-442. IF:4.083. 1These authors contributed equally to this work.

Aguilar M,  González-Candia A, Rodríguez J, Carrasco-Pozo C,  Cañas D,  García C,  Herrera EA, Castillo R. Mechanisms of cardiovascular protection associated with intermittent hypobaric hypoxia exposure in a rat model: role of oxidative stress. International Journal of Molecular Sciences. 2018.  26;19. IF: 3.226

Carrasco-Pozo C*, Tan K.N, Gotteland M, Borges K. Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Cellular Longevity. 2017; 2017:3839756. IF: 4.936

Cires MJ, Wong X, Carrasco-Pozo C*, Gotteland M. The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins. Frontiers in Nutrition. 2017; 3:57. (IF available in 2019)

Fuentes J, Atala E, Pastene E, Carrasco-Pozo C, Speisky H. Quercetin oxidation paradoxically enhances its antioxidant and cytoprotective properties. Journal of Agricultural and Food Chemistry. 2017; 65:11002-10. IF: 3.154

Tan K.N1, Carrasco-Pozo C1, McDonald T, Puchowicz M, Borges K. Tridecanoin is anticonvulsant, antioxidant and improves mitochondrial function. Journal of Cerebral Blood Flow & Metabolism. 2017; 37:2035-2048. IF: 5.081. 1These authors contributed equally to this work.

Farías JG, Carrasco-Pozo C, Sepúlveda N, Álvarez P, Quezada M, Quiñones J, Short SE, Castillo RL. Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2. Experimental Biology and Medicine (Maywood). 2017; 242:1104-14. IF 2.542.

McDonald T, Carrasco-Pozo C, Hodson MP, Borges K. Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model. eNeuro. 2017; 4. IF (available in 2018)

Carrasco-Pozo C*, Tan K.N, Reyes-Farias M, de la Jara N, Ngo S.T, Garcia-Diaz D.F, Llanos P, Cires M.J, Borges K. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies. Redox Biology. 2016; 9:229-43. IF: 7.126

Farías J.G, Herrera E.A, Carrasco-Pozo C, Sotomayor-Zárate R, Cruz G, Morales P, Castillo R.L. Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress. Pharmacology & Therapeutics. 2016; 158:1-23. IF: 10.376

Carrasco-Pozo C*, Castillo RL, Beltrán C, Miranda A, Fuentes J, Gotteland M. Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2. Journal of Nutritional Biochemistry. 2016; 27:289-98. IF: 4.414

Wong X, Madrid A.M, Tralma K, Castillo R, Carrasco-Pozo C, Navarrete P, Beltran C, Pastene E, Gotteland M. Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers. Journal of Functional Foods. 2016; 26:406-17. IF: 3.144.

Morales P, Fujio S, Navarrete P, Ugalde JA, Magne F, Carrasco-Pozo C, Tralma K, Quezada M, Hurtado C, Covarrubias N, Brignardello J, Henriquez D, Gotteland M. Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers. Clinical and Translational Gastroenterology. 2016; 7:e161. IF 3.472.

Wong X, Carrasco-Pozo C, Escobar E, Navarrete P, Blachier F, Andriamihaja M, Lan A, Cires MJ, Pastene E, Gotteland M. Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites. Journal of Agricultural and Food Chemistry. 2016; 64:3574-83. IF 3.154.

Vergara D, Avila D, Escobar E, Carrasco-Pozo C, Sanchez A, Gotteland M. The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers – an explorative study. Nutrition Journal. 2015; 14:27. IF 3.265.

Herrera EA, Farías JG, González-Candia A, Short SE, Carrasco-Pozo C, Castillo RL. Ω3 supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats. Marine Drugs. 2015; 13:838-60. IF 3.345.

Andriamihaja M, Lan A, Beaumont M, Audebert M, Wong X, Yamada K, Yin Y, Tomé D, Carrasco-Pozo C, Gotteland M, Kong X, Blachier F. The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells. Free Radical Biology and Medicine 2015; 85:219-227. IF 6.02

Carrasco-Pozo C, Tan K.N, Borges K. Sulforaphane is anticonvulsant and improves mitochondrial function. Journal of Neurochemistry. 2015; 135:932-42. IF 4.609

Carrasco-Pozo C*, Gotteland M, Castillo R.L., Chen C. 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Experimental Cell Research. 2015; 334:270-82. IF 3.309.

Gotteland M, Cires MJ, Carvallo C, Vega N, Ramirez MA, Morales P. Rivas P, Astudillo F, Navarrete P, Dubos C, Figueroa A, Troncoso M, Ulloa C, Mizgier ML, Carrasco-Pozo C, Speisky H, Brunser O, Figueroa G. Probiotic screening and safety evaluation of Lactobacillus strains from plants, artisanal goat cheese and human stool and milk. Journal of Medicinal Food. 2014; 17:487-95. IF 1.844.

Peña, F.; Mizgier, M. L.; Morales, P.; Rios, I.; Carrasco-Pozo, C.; Diaz, E.; Brunser, O.; Gotteland, M. Effect of the Synbiotic (B. animalis spp. lactis Bb12 + Oligofructose) in Obese Subjects. A Randomized, Double-Blind, Controlled Clinical Trial. Journal of Food and Nutrition Research. 2014; 2:491-498.

Carrasco-Pozo C*, Morales P, Gotteland M. Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression. Journal of Agricultural and Food Chemistry. 2013; 61:5291-7.

 Carrasco-Pozo C*, Pastene E, Vergara C, Zapata M, Sandoval C, Gotteland M. Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells: modulation by the polyphenols quercetin, resveratrol and rutin. Biochim Biophys Acta. 2012; 1820:2052-61.

Carrasco-Pozo C*, Mizgier ML, Speisky H, Gotteland M. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact. 2012; 195:199-205.

Carrasco-Pozo C*, Gotteland M, Speisky H. Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition. J Agric Food Chem. 2011; 59:11501-8.

Carrasco-Pozo C*, Speisky H, Brunser O, Pastene E, Gotteland M. Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats. J Agric Food Chem. 2011; 59:6459-66.

Aliaga ME, Carrasco-Pozo C, López-Alarcón C, Olea-Azar C, Speisky H. Superoxide-dependent reduction of free Fe(3+) and release of Fe(2+) from ferritin by the physiologically-occurring Cu(I)-glutathione complex. Bioorg Med Chem. 2011; 19:534-41.

Carrasco-Pozo C*, Gotteland M, Speisky H. Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells. J Pharm Pharmacol. 2010; 62:943-50.

Aliaga, M. E.; Carrasco-Pozo, C.; Lopez-Alarcon, C.; Speisky, H. The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species. Transition Metal Chemistry. 2010; 35: 321–9.

Rodríguez J, Arán VJ, Boiani L, Olea-Azar C, Lavaggi ML, González M, Cerecetto H, Maya JD, Carrasco-Pozo C, Cosoy HS. New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies. Bioorg Med Chem. 2009; 17:8186-96.

Carrasco-Pozo C*, Aliaga ME, Olea-Azar C, Speisky H. Double edge redox-implications for the interaction between endogenous thiols and copper ions: In vitro studies. Bioorg Med Chem. 2008; 16:9795-803.

Speisky H, Gómez M, Carrasco-Pozo C, Pastene E, Lopez-Alarcón C, Olea-Azar C. Cu(I)-glutathione complex: a potential source of superoxide radicals generation. Bioorg Med Chem. 2008; 16:6568-74.

O’Brien P, Carrasco-Pozo C, Speisky H. Boldine and its antioxidant or health-promoting properties. Chem Biol Interact. 2006; 159:1-17

Carrasco-Pozo C, Alvarez-Lueje A, Olea-Azar C, López-Alarcón C, Speisky H. In vitro interaction between homocysteine and copper ions: Potential redox implications. Exp Biol Med (Maywood). 2006; 231:1569-75.

Speisky H, Rocco C, Carrasco C, Lissi EA, López-Alarcón C. Antioxidant screening of medicinal herbal teas. Phytother Res. 2006; 20:462-7.

López-Alarcón C, Rocco C, Lissi E, Carrasco C, Squella JA, Nuñez-Vergara L, Speisky H. Reaction of 5-aminosalicylic acid with peroxyl radicals: protection and recovery by ascorbic acid and amino acids. Pharm Res. 2005; 22:1642-8.

Book Chapters:

Carrasco-Pozo C. Chapter 57 – Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity. Polyphenols in Human Health and Disease. Academic Press, Elsevier. Volume 1, 2014;1:731-46

Carrasco-Pozo C, Mizgier ML. Chapter 10 – Intestinal absorption and metabolism of dietary polyphenols and Vitamin C. Gastrointestinal Physiology and Nutrition. Nestle, Chile, 2013

Grants and Awards:   

FONDECYT REGULAR COMPETITION N°1171550, CHILE (2017-2020) “The use of a polyphenol-rich extract from Berberis microphylla (calafate) over obesity and diabetes development: an in vivo analysis of the mechanisms involved” Role: CIB. USD 300,000

FONDECYT INITIATON INTO RESEARCH N° 11130232, CHILE (2013 – 2017) “Molecular and cellular basis of the protective effect of quercetin and its microbial metabolite 3,4-dihydroxyphenylacetic acid against the pancreatic β-cell dysfunction induced by cholesterol. In vitro and in vivo studies”. Role: CIA. USD 170,000

SOCHINUT/NESTLE-GRANT, CHILE (2016-2017) “Absorption of polyphenols; effect of hypolactasia and administration of exogenous lactase, a clinical study”. Role: CIA. USD 6,000

ECOS/CONICYT (France-Chile collaboration) (2013-2016) “Protective effects of proanthocyanidins and of their bacterial metabolites on human colonic epithelial cells exposed to H2S and p-cresol”. Role: Associate Investigator USD 14,000

FONDECYT REGULAR COMPETITION N°1120290, CHILE (2012-2016) “Reduction of fat absorption, and low grade endotoxinemia Inflammation by dietary proanthocyanidins as a strategy for the prevention of metabolic syndrome and its complications – An in vitro, animal and human study”. Role: CIB USD 300,000

FONDECYT POSTDOCTORATE FELLOWSHIP N° 3110177, CHILE (2010-2013) “Evaluation of the gastro-protective effect of dietary polyphenols against mitochondrial, cellular, inflammatory and functional damage induced by indomethacin in the gastrointestinal tract”. USD 90,000

Prizes, Awards, Recognition, Scholarships:

  • 2016. Henry Nestle Award, Nestle, Chile.
  • 2017. Recognition Award – Top 6% Publication productivity of University of Chile
  • 2015. Research Award “Universia Santander” ECR-Team Category, Chile (USD 30,000)
  • 2010 Stekel Scholarship, Institute of Nutrition and Food Technology, University of Chile
  • 2010. PhD scholarship extension, National Commission for Scientific and Technological Research, CONICYT, Chile
  • 2006-2009. PhD Scholarship, National Commission for Scientific and Technological Research, CONICYT, Chile
  • 1999 – 2004. Academic Excellence Award “President of the Republic of Chile”, Chilean Government