Jose de Brito
Name: Jose de Brito
Position: PhD student
Research Area: Cancer Drug Discovery
Qualifications: BSc (Hons), MSc.
Biography: 
Jose completed his undergraduate degree in Biology from the Federal University of Ceara, Brazil in 2017. He completed his Master’s degree in Pharmacology from the Federal University of Ceara (UFC) in 2019.
In 2019, he commenced his Ph.D. study in the field of immunoliposome development for the treatment of prostate cancer. Jose’s Ph.D. project title is: Immunoliposome anti-EGFR loaded with antimitotic compound for site-specific release in metastatic prostate cancer:3D cell culture model.
Jose joined Discovery Biology as a Visiting Scholar in September 2022, to evaluate the anticancer activity of novel antimitotic compounds.
Publication:
Filho EC, Antoniazi MK, Ferreira RQ, dos Santos GFS, Pessoa C, Guimarães CJ, Neto JBV, Silva AMS, Greco SJ. A Green Multicomponent Domino Mannich‐Michael Reaction to Synthesize Novel Naphthoquinone‐Polyphenols with Antiproliferative and Antioxidant Activities. European Journal of Organic Chemistry. 2022 June; e202200442.
Moraes de Farias K, Rosa‐Ribeiro R, Souza E, Kobarg J, Banwell M, Neto JBV et al. The Isoflavanoid (+)‐PTC Regulates Cell‐Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line. Chemistry & Biodiversity. 2022 May;19(5): e202200102.
Santos E da S, Nogueira KAB, Fernandes LCC, Martins JRP, Reis AVF, Neto JBV, et al. EGFR targeting for cancer therapy: Pharmacology and immunoconjugates with drugs and nanoparticles. International Journal of Pharmaceutics. 2021 Jan;5(592):120082.
Gontijo TB, de Freitas RP, Emery FS, Pedrosa LF, Neto JBV, Cavalcanti BC, et al. On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells. Bioorganic Med Chem Lett. 2017 Sep 15;27(18):4446-4456.
