Griffith University

Kah Ni Tan

Name: Kah Ni Tan
Position: Research Assistant
Research Area: Cancer
Qualifications: BBiotech (Hons 1), PhD (thesis under review)

Biography: Kah Ni completed her Bachelor of Biotechology (Hons 1) with major in Drug Design and Development from The University of Queensland in 2013. She then worked as a research assistant in the School of Biomedical Sciences for six months before starting her PhD at The University of Queensland in 2014. She undertook a PhD project to investigate the potential of medium-chain triglycerides as treatment options for refractory epilepsy and ischaemic stroke in rodent models, by understanding their effects on mitochondrial function and oxidative stress. She joined Discovery Biology as a research assistant with Professor Vicky Avery in February 2018.

Other: University of Queensland

Publications:

Tan KN, Simmons D, Carrasco-Pozo C* & Borges K*. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry. Accepted December 2017.

Carrasco-Pozo C, Tan KN, Gotteland M & Borges K. Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Celullar Longevity. 2017, 3839756.

Carrasco-Pozo C, Tan KN, Reyes-Farias M, De La Jara N, Ngo ST, Garcia-Diaz DF, Llanos P, Cires MJ & Borges K. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biology. 2016, 9:229-243.

Tan KN*, Carrasco-Pozo C*, McDonald TS, Puchowicz M & Borges K. Tridecanoin is anticonvulsant, antioxidant and improves mitochondrial function. Journal of Cerebral Blood Flow & Metabolism. 2016, 37:2035-2048.

Tefera TW, Tan KN, McDonald TS & Borges K. Alternative fuels in epilepsy and Amyotrophic Lateral Sclerosis. Neurochemical Research. 2016, 46:1610-1620.

Carrasco-Pozo C*, Tan KN* & Borges K. Sulforaphane is anticonvulsant and improves mitochondrial function. Journal of Neurochemistry. 2015, 135: 932-942.

Hadera MG, Smeland OB, McDonald TS, Tan KN, Sonnewald U & Borges K. Triheptanoin partially restores levels of tricarboxylic acid intermediates in the mouse pilocarpine model of epilepsy. Journal of Neurochemistry. 2014, 129: 107-119.

McDonald T, Tan KN, Hodson M & Borges K. Alterations of hippocampal glucose metabolism by even vs. uneven medium chain triglycerides. Journal of Cerebral Blood Flow & Metabolism. 2014, 34: 153-160.

Shaikh MF, Tan KN & Borges K. Anticonvulsant screening of luteolin in four mouse seizure models. Neuroscience Letter. 2013, 550: 195-199.

* Denotes equal contribution

Book Chapter:

Tan KN, McDonald TS & Borges K. Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches, in Watson R (ed.), Bioactive nutraceuticals and dietary supplements in neurological and brain disease, Academic Press, 2015, pp. 461-469.

Scholarship/University Awards:

2014-2017: International Postgraduate Research Scholarship (IPRS), University of Queensland

2014-2017: University of Queensland Centennial Scholarship (UQCent)

2013: Dean’s Commendation for High Achievement, University of Queensland, Australia

2012: Dean’s Commendation for High Achievement, University of Queensland, Australia

2009: Dean’s Commendation for High Achievement, University of Queensland, Australia

Travel Awards:

2017: Faculty of Medicine Travel Scholarship, University of Queensland, Australia

2017: Early Career Investigator Travel Bursary

2016: Specialty Feeds Scientific Award

Conferences:

Tan KN, Carrasco-Pozo C & Borges K. Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus. BRAIN & BRAIN PET in Berlin, Germany, April 2017.

Tan KN, Carrasco-Pozo C & Borges K. Triheptanoin preserves mitochondrial function and prevents oxidative stress in a mouse seizure model. 7th International Postgraduate Student Symposium in Brisbane, Australia, November 2016.

Tan KN, Carrasco-Pozo C, Puchowicz M & Borges K. Antioxidant and anticonvulsant effects of tridecanoin, the triglyceride of decanoate. Society for Neuroscience in Chicago, USA, October 2015.

Tan KN, Carrasco-Pozo C & Borges K. Sulforaphane is anticonvulsant and preserves mitochondrial functions in mouse seizure models. 5th International Postgraduate Student Symposium in Brisbane, Australia, November 2014.

Tan KN, McDonald T, Smeland OB, Sonnewald U & Borges K. Metabolic dysfunction during seizure development in mouse pilocarpine model. American Epilepsy Society in Washington DC, USA, November 2013.

Tan KN, McDonald T, Hadera M, Smeland O, Sonnewald U & Borges K. Glucose entry into the citric acid cycle is decreased in epileptic mice. Australian Neuroscience Society Annual Meeting, Melbourne, Australia, February 2013.