Griffith University

Todd Shelper

Name: Todd Shelper
Position: Research Fellow
Research Area: Leishamania
Qualifications: BAppSci, MBiotech, PhD

Biography: Todd completed his degree in 2001 at QUT and Masters of Biotechnology at UQ in 2005. He undertook his Masters research in the cell cycle laboratory at the Diamantina Institute, investigating the mechanisms behind histone deacetylase inhibitors. During his academic studies, Todd worked in a chemical manufacturing company for 7 years. In 2008 he joined the Discovery Biology team as a research assistant, working on commercial high throughput screening projects. He completed his PhD in November 2014, focusing on the development of more biologically relevant pancreatic cancer cell 3D models for use in anti-cancer drug discovery programs. Todd is currently working on establishing a high content imaging based assay for screening compounds against the Leishmania parasite.

Discovery Biology:

Publications:

Shelper TB, Lovitt CJ, and Avery VM. Assessing Drug Efficacy in a Miniaturized Pancreatic Cancer in vitro 3D Cell Culture Model. ASSAY and Drug Development Technologies. [Special edition] 2016 Sep; 14(7): 367-380.

Lovitt C,  Shelper T and  Avery VM. Cancer Drug Discovery: Recent Innovative Approaches to Tumor Modeling. Expert Opinion On Drug Discovery. [Invited review]. 2016 Jul 25. [Epub ahead of print] PMID: 27454169.

Sittampalam S, Eglen R, Ferguson S, Maynes JT, Olden K, Schrader L, Shelper T, Ferrer M. Assay Drug Dev Technol. 2015 Jun; 13(5): 254-261.

Lovitt CJ, Shelper TB and Avery VM. Evaluation of chemotherapeutics in a three-dimensional breast cancer model. Journal of Cancer Research and Clinical Oncology. 2015 May; 141(5): 951-959.

Davis RA, Beattie KD, Xu M, Yang X, Yin S, Holla H, Healy PC, Sykes M, Shelper T, Avery VM, Elofsson M, Sundin C, and Quinn RJ.  Solving the Supply of Resveratrol Tetramers from Papua New Guinean Rainforest Anisoptera Species That Inhibit Bacterial Type III Secretion Systems. J Nat Prod.  2014 Dec 26; 77(12): 2633-2640.

Lovitt CJ, Shelper TB and Avery VM. Advanced cell culture techniques for cancer drug discovery. Biology. [invited review] 2014 May 30; 3(2): 345-367.

Lovitt CJ*, Shelper TB* and Avery VM. Miniaturized three-dimensional cancer model for drug evaluation.  ASSAY and Drug Development Technologies. September 1 2013, 11(7): 435-448. * Equal first author.

Xu M, Davis RA, Feng Y, Sykes ML, Shelper T, Avery VM, Camp D, and Quinn RJ. Ianthelliformisamines A-C: Antibacterial Bromotyrosine-derived Metabolites from the Marine Sponge Suberea ianthelliformisJournal Nat Prod. 2012 May 25; 75(5): 1001-1005.

Yu M, Price JR, Jensen P, Lovitt CJ, Shelper T, Duffy S, Windus LC, Avery VM, Rutledge PJ and Todd MH. Copper, Nickel, and Zinc Cyclam-Amino Acid and Cyclam-Peptide Complexes may be Synthesized with “Click” Chemistry and Are Noncyctotoxic. Inorg Chem. 2011 Dec 19; 50(24): 12823-12835.

Martin F, Grkovic T, Sykes ML, Shelper T, Avery VM, Camp D, Quinn RJ and Davis RA. Alkaloids from the Chinese Vine Gnetum montanum. J Nat Prod. 2011 Nov 28; 74(11): 2425-2430.

Yin S, Davis RA, Sykes ML, Shelper T, Avery VM, Elofsson M, Sundin C and Quinn RJ. Pseudoceramines A-D, antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp. Organic & Biomolecular Chemistry. 2011 Sep 9; 9(19): 6755-6760.

Yin S, Sykes ML, Davis RA, Shelper T, Avery VM, Camp D, Quinn RJ. New Galloylated Flavanonols from the Australian Plant, Glochidion sumatranum . Planta Medica. 2010 Nov; 76(16): 1877-1881.

Awards:

Travel award – Tony B Academic Travel award (SLAS, 2016)

Travel award – HCS (RNAi, 2015)

Travel Award – CTx (Australian High Content Screening and RNAi Group meeting, 2013)

APA PhD Scholarship (2011-2014)

Eskitis PhD Top-up Scholarship (2011-2014)

Travel Award – CRC CTx (AHCSM, 2012)

Travel Award – Griffith Travel Scholarship (ISRF, 2012)

Conferences:

The Society for Laboratory Automation and Screening (SLAS); (San Diego, USA, 2016) – Poster

Australian High content Screening and RNAi Group meeting (Melbourne, 2015) – Presentation

10th Annual High-Content Analysis Meeting (San Francisco, USA, 2013) – Presentation

Australian High content Screening and RNAi Group meeting (Melbourne, 2013) – Presentation

Australian Pancreatic Club Annual Scientific Meeting (Melbourne, 2013) – Presentation

International Student Research Forum (Gold Coast, 2013) – Session Chair/Committee Member

9th Annual High-Content Analysis Meeting (San Francisco, USA, 2012)

24th Lorne Cancer Conference (Lorne, Australia, 2012) – Poster

ASMR Queensland Postgraduate Student Conference (Brisbane, Australia, 2012) – Poster

6th Australian High Content Screening Group Meeting  (Melbourne, Australia, 2012)

International Student Research Forum (Omaha, USA, 2012) – Presentation

14th International Biennial Conference on Metastasis Research (Brisbane, Australia, 2012)

Brisbane Cell and Developmental Biology Meeting (Brisbane, Australia, 2012)