Griffith University




Zhang C, Lum KY, Taki AC, Gasser RB, Byrne JJ, Montaner LJ, Tietjen I,  Avery VM, Davis RA. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations. Journal of Natural Products. 2023 Feb 17.

Sykes ML, Kennedy EK,  Avery VM.  Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity. Microorganisms. 2023 Feb 14 ;11(2):476.

Albertyn CC, van Niekerk A, Duffy S, Avery VM, Strauss E, Chellan P. Investigation of bioorganometallic artemisinins as antiplasmodials. Journal of Organometallic Chemistry. 2023 Feb 3:122633.

Lum KY, White JM, Johnson DJ,  Avery VM, Davis RA. Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds. Beilstein Journal of Organic Chemistry. 2023 Jan 31;19(1):107-14.


Ang CW, Lee BM, Jackson CJ, Wang Y, Franzblau SG, Francisco AF, Kelly JM, Bernhardt PV, Tan L, West NP, Sykes ML, Hinton AO, Bolisetti R, Avery VM, Cooper MA, Blaskovich MAT. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. Journal of Medicinal Chemistry. 2022 Sep 16.

Duffy S,  Avery VM.  Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia.  Microbiology Spectrum. 2022 Sep 12:e0128221.

Sykes ML, Kennedy EK, Read KD, Kaiser M, Avery VM. Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma bruceiMicroorganisms. 2022 Jun 25;10(7):1287.

Jordaan L, Ndlovu MT, Mkhize S, Ngubane S, Loots L, Duffy S,  Avery VM, Chellan P. Investigating the antiplasmodial activity of substituted cyclopentadienyl rhodium and iridium complexes of 2-(2-pyridyl)benzimidazole. Journal of Organometallic Chemistry. 2022  Mar 15;962:122273.

Zulfiqar B and Avery VM. Assay development in leishmaniasis drug discovery: a comprehensive review. Expert Opinion on Drug Discovery. 2022 Feb;17(2):151-166.

Holland DC, Prebble DW, Er S, Hayton JB, Robertson LP, Avery VM, Domanskyi A, Kiefel MJ, Hooper JNA, Carroll AR. α-Synuclein Aggregation Inhibitory Prunolides and a Dibrominated β-Carboline Sulfamate from the Ascidian Synoicum prunumJournal of Natural Products. 2022 Jan 20;85(2):441-52.

Nugraha, AS, Purnomo, YD, Widhi Pratama, AN, Triatmoko, B, Hendra, R, Wongso, H, Avery, VM, Keller, PA. Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia Mahagoni and Pluchea Indica. Natural Product Communications. 2022 Jan 17:(1):1934578X211068926.


Devine SM, Challis MP, Kigotho JK, Siddiqui G, De Paoli A, MacRaild CA, Avery VM, Creek DJ, Norton RS, Scammells PJ. Discovery and development of 2-aminobenzimidazoles as potent antimalarials. European Journal of Medicinal Chemistry. 2021 Oct 5;221:113518.

Ellis KM, Lucantoni L, Chavchich M, Abraham M, De Paoli A, Luth MR, Zeeman AM, Delves MJ, Terán FS, Straschil U, Baum J, Kocken CHM, Ralph SA, Winzeler EA, Avery VM, Edstein MD, Baell JB, Creek DJ. The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. Antimicrobial Agents and Chemotherapy. 2021 Oct 18;65(11):e0031121.

Ashton TD, Ngo A, Favuzza P, Bullen HE, Gancheva MR, Romeo O, Schneider MP, Nguyen N, Steel RWJ, Duffy S, Lowes KN, Sabroux HJ, Avery VM, Boddey JA, Wilson DW, Cowman AF, Gilson PR and Sleebs BE. Property Activity Refinement of 2‑Anilino 4‑Amino Substituted Quinazolines as Antimalarials with Fast Acting Asexual Parasite Activity. Bioorganic Chemistry. 2021 Sep 21.

Laleu B, Akao Y, Ochida A, Duffy S, Lucantoni L, Shackleford D, Chen G, Katneni K, Chiu F, White K, Chen X, Sturm A, Dechering K, Crespo B, Sanz L, Wang B, Wittlin S, Charman S, Avery VM, Cho N and Kamaura M. Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. Journal of Medicinal Chemistry. 2021 Sep 9; 64(17): 12582-12602.

Okaniwa M, Shibata A, Ochida A, Akao Y, White KL, Shackleford DM, Duffy S, Lucantoni L, Dey S, Striepen J, Yeo T, Mok S, Aguiar ACC, Sturm A, Crespo B, Sanz LM, Churchyard A, Baum J, Pereira DB, Guido RVC, Dechering KJ, Wittlin S, Uhlemann AC, Fidock DA, Niles JC, Avery VM, Charman SA and Laleu B. Repositioning and Characterization of 1-(pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors. ACS Infectious Diseases. 2021 Jun 11; 7(6): 1680-1689.

Håheim KS, Lindbäck E, Tan KN, Albrigtsen M, Urdal Helgeland IT, Lauga C, Matringe T, Kennedy EK, Andersen JH, Avery VM and Sydnes MO. Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities. Molecules. 2021 May 30; 26(11): 3268.

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E. Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M. Avery, Miriam S. Butler, Michelle A. Camerino, Catalina Carrasco-Pozo, Susan A. Charman, Melissa J. Davis, Mark A. Dawson, Dawson Sarah-Jane, Melanie de Silva, Matthew L. Dennis, Olan Dolezal, Rachel Lagiakos, Geoffrey J. Lindeman, Laura MacPherson, Stewart Nuttall, Thomas S. Peat, Bin Ren, Alexandra E. Stupple, Elliot Surgenor, Chin Wee Tan, Tim Thomas, Jane E. Visvader, Anne K. Voss, Francois Vaillant, Karen L. White, James Whittle, Yuqing Yang, Soroor Hediyeh-Zadeh, Paul A. Stupple, Ian P. Street, Brendon J. Monahan, Thomas Paul. First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1130.

 Johnson DJG, Jenkins ID, Huxley C, Coster MJ, Lum KY, White JM, Avery VM and RA Davis RA. Synthesis of New Triazolopyrazine Antimalarial Compounds. Molecules. 2021 Apr 21; 26(9): 2421.

Priebbenow DL, Mathiew M, Shi DH, Harjani JR, Beveridge JG, Chavchich M, Edstein MD, Duffy S, Avery VM, Jacobs RT, Brand S, Shackleford DM, Wang W, Zhong L, Lee G, Tay E, Barker H, Crighton E, White KL, Charman SA, De Paoli A, Creek DJ and Baell JB. Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-Triazines. Journal of Medicinal Chemistry. 2021 Apr 8; 64(7): 4150-4162.

Chellan P, Avery VM, Duffy S, Land KM, Tam CC, Kim JH, Cheng LW, Romero-Canelón I and Sadler PJ. Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin. Journal of Inorganic Biochemistry. (50-year anniversary issue). 2021 Mar 3; 2021 Mar 3; 219: 111408.

Nguyen W, Dans MG, Ngo A, Gancheva MR, Romeo O, Duffy S, de Koning-Ward TF, Lowes KN, Sabroux HJ, Avery VM, Wilson DW, Gilson PR and Sleebs BE. Structure Activity Refinement of Phenylsulfonyl Piperazines as Antimalarials that Block Erythrocytic Invasion. European Journal of Medicinal Chemistry. 2021 Mar 15; 214: 113253.

Kotzé TJ, Duffy S, Avery VM, Jordaanc A, Warner DF, Loots L, Smith GS and Chellan P. Synthesis and antimicrobial study of organoiridium amido-sulfadoxine complexes. Inorganica Chimica Acta. 2021 March 1; 517: 120175.

Kaemmerer E, Loessner D and Avery VM. Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy. Drug Discovery Today. [Review] 2021 Mar; 26(3): 663-676.

Hiranrat A, Holland DC, Mahabusarakam W, Hooper JNA, Avery VM and Carroll AR. Tedaniophorbasins A and B—Novel Fluorescent Pteridine Alkaloids Incorporating a Thiomorpholine from the Sponge Tedaniophorbas ceratosis. Marine Drugs. 2021 Feb 7; 19(2): 95.


Prebble DW, Holland DC, Robertson LP, Avery VM and Carroll AR. Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra. Organic Letters. 2020 Dec 18; 22(24): 9574-9578.

Ang CW, Tan L, Sykes ML, AbuGharbiyeh N, Debnath A, Reid JC, West NP, Avery VM, Cooper MA and Blaskovich MAT. Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. Journal of Medicinal Chemistry. 2020 Dec 24; 63(24): 15726-15751.

Kleks G, Holland DC, Kennedy EK, Avery VM and Carroll AR. Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi. Journal of Natural Products. 2020 Nov 25; 83(11): 3435-3444.

Carrasco-Pozo C, Tan KN and Avery VM. Hemin Prevents Increased Glycolysis in Macrophages upon Activation: Protection by Microbiota-Derived Metabolites of Polyphenols. Antioxidants. 2020 Nov 11; 9(11): E1109.

Zandi L, Makungu M, Munissi JJE, Duffy S, Puttreddy R, von der Heiden D, Rissanen K, Avery VM, Nyandoro SS and Erdélyi M. Secoiridoids and Iridoids from Morinda asteroscep. Journal of Natural Products. 2020 Sep 25; 83(9): 2641-2646.

Brown RW,  Abdel-Megeed AM, Keller PA, Jones AJ, Sykes ML, Kaiser M, Baell JB, Avery VM and Hyland CJT. Investigation of thiazolyl–benzothiophenamides as potential agents for African sleeping sickness. RSC Medicinal Chemistry. 2020 Sept 23; 11: 1413-1422.

Thompson AM, O’Connor PD, Marshall AJ, Francisco AF, Kelly JM, Riley J, Read KD, Perez CJ, Cornwall S, Thompson RCA, Keenan M, White KL, Charman SA, Zulfiqar B, Sykes ML, Avery VM, Chatelain E and Denny WA. Re-evaluating pretomanid analogues for Chagas disease: hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. European Journal of Medicinal Chemistry. 2020 Sep 18; 207: 112849.

Tan KN, Avery VM and Carrasco-Pozo C. Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer. International Journal of Molecular Science. [Review] 2020 Sep 10; 21(18): E6622.

Atilaw Y, Muiva-Mutisya L, Bogaerts J, Duffy S, Valkonen A, Heydenreich M, Avery VM, Rissanen K, Erdélyi M and Yenesew A. Prenylated Flavonoids from the Roots of Tephrosia rhodesica. Journal of Natural Products. 2020 Aug 28; 83(8): 2390-2398.

Collins KA, Wang CY, Adams M, Mitchell H, Robinson GJ, Rampton M, Elliott S, Odedra A, Khoury D, Ballard E, Shelper TB, Lucantoni L, Avery VM, Chalon S, Möhrle JJ and McCarthy JS. A Plasmodium vivax experimental human infection model for evaluating the efficacy of interventions. The Journal of Clinical Investigation. 2020 Jun 1; 130(6): 2920-2927.

McNamara N, Rahmani R, Sykes ML, Avery VM and Baell J. Hit-to-lead Optimization of Novel Benzimidazole Phenylacetamides as Broad Spectrum Trypanosomacides. RCS Medicinal Chemistry. 2020 May 29; 11(6): 685-695.

Begum S, Munissi JJE, Buriyo AS, Makangara JJ, Lucantoni L, Avery VM, Erdelyi M and Nyandor SS. Antiplasmodial, Antimicrobial and Cytotoxic Activities of Extracts from Selected Medicinal Plants Growing in Tanzania. Journal of Biologically Active Products from Nature. 2020 May 22; 10 (2): 165-176.

Sykes ML, Hilko DH, Kung LI, Poulsen SA and Avery VM. Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites. PLOS Neglected Tropical Diseases. 2020 Mar 12; 14(3): e0008068.

Maeda G, Munissi JJE, Lindblad S, Duffy S, Pelletier J, Avery VM, Nyandoro SS and Erdélyi M. A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis. Journal of Natural Products. 2020 Feb 28; 83(2): 316-322.

Kleks G, Duffy S, Lucantoni L, Avery VM, Carroll AR. Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia. Journal of Natural Products. 2020 Feb 28; 83(2): 422-428.

MacPherson L, Anokye J, Yeung MM, Lam EYN, Chan YC, Weng CF, Yeh P, Knezevic K, Butler MS, Hoegl A, Chan KL, Burr ML, Gearing LJ, Willson T, Liu J, Choi J, Yang Y, Bilardi RA, Falk H, Nguyen N, Stupple PA, Peat TS, Zhang M, de Silva M, Carrasco-Pozo C, Avery VM, Khoo PS, Dolezal O, Dennis ML, Nuttall S, Surjadi R, Newman J, Ren B, Leaver DJ, Sun Y, Baell JB, Dovey O, Vassiliou GS, Grebien F, Dawson SJ, Street IP, Monahan BJ, Burns CJ, Choudhary C, Blewitt ME, Voss AK, Thomas T and Dawson MA. HBO1 is required for the maintenance of leukaemia stem cells. Nature. 2020 Jan 9; 577(7789): 266-270.

Robertson LP, Lucantoni L, Avery VM and Carroll AR. Antiplasmodial Bis-Indole Alkaloids from the Bark of Flindersia pimenteliana. Planta Medica. 2020 Jan; 86(1): 19-25.


Varghese S, Rahmani R, Russell S, Deora G, Ferrins L, Toynton A, Jones A, Sykes M, Kessler A, Eufrásio A, Cordeiro A, Sherman J, Rodriguez A, Avery VM, Piggott MJ and Baell JB. Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi. ACS Medicinal Chemistry Letters. 2019 Sep 9; 11(3): 278-285.

Jennison C, Lucantoni L, O’Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM and Boddey JA. Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes. Cell Reports. 2019 Dec 17; 29(12): 3796-3806.

Carrasco-Pozo C, Tan KN, Rodriguez T and Avery VM. The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor. International Journal of Molecular Science. 2019 Oct 29; 20(21): 5384.

Klejch T, Keough DT, Chavchich M, Travis J, Skácel J, Pohl R, Janeba Z, Edstein MD, Avery VM, Guddat LW, Hocková D. Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation. European Journal of Medicinal Chemistry. 2019 Sep 4; 183: 111667.

Butler NM, Bremner JB, Willis AC, Lucantoni L, Avery VM, Keller PA. Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1H,3'H]-3-Aryl-2,2′-diindol-3′-ones. The Journal of Organic Chemistry. 2019 Sep 6; 84(17): 11228-11239.

Nyandoro SS, Maeda G, Munissi JJE, Gruhonjic A, Fitzpatrick PA, Lindblad S, Duffy S, Pelletier J, Pan F, Puttreddy R, Avery VM, Erdélyi M. A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys Kirkii. Molecules. 2019 Jul 29; 24(15): 2746.

Pullella GA, Wdowiak AP, Sykes ML, Lucantoni L, Sukhoverkov KV, Zulfiqar B, Sobolev AN, West NP, Mylne JS, Avery VM, Piggott MJ. Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone. Organic Letters. Jul 19; 21(14): 5519-5523.

Houston SD, Fahrenhorst-Jones T, Xing H, Chalmers BA, Sykes ML, Stok JE, Farfan Soto C, Burns JM, Bernhardt PV, De Voss JJ, Boyle GM, Smith MT, Tsanaktsidis J, Savage GP, Avery VM and Williams CM. The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic & Biomolecular Chemistry. 2019 Jul 17; 17(28): 6790-6798.

Norcross NR, Wilson C, Baragaña B, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Fletcher D, Sinden R, Delves M, Ruecker A, Duffy S, Meister S, Antonova-Koch Y, Crespo B, de Cózar C, Sanz LS, Gamo FJ, Avery VM, Frearson JA, Gray DW, Fairlamb AH, Winzeler EA, Waterson D, Campbell SF, Willis PA, Read KD, Gilbert IH. Substituted Aminoacetamides as Novel Leads for Malaria Treatment. ChemMedChem. 2019 Jul 17; 14(14): 1329-1335.

Robertson LP, Lucantoni L, Duffy S, Avery VM and Carroll AR. Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens. Journal of Natural Products. 2019 Apr 26; 82(4): 1019-1023.

Xue L, Shi DH, Harjani JR, Huang F, Beveridge J, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell SA, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek DJ, Price R, Marfurt J, Charman SA, Cuellar M, Strasser J, Dahlin J, Walters MA, Edstein M, Avery VM and Baell JB. 3,3’-Disubstituted 5,5’-Bi(1,2,4-triazine) Derivatives with Potent In Vitro and In Vivo Antimalarial Activity. Journal of Medicinal Chemistry. 2019 Mar 14; 62(5): 2485-2498.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ and McGowan S. Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. Journal of Medicinal Chemistry. 2019 62(2): 622-640.

Leven M, Held J, Duffy S, Alves Avelar LA, Meister S, Delves M, Plouffe D, Kuna K, Tschan S, Avery VM, Winzeler EA, Mordmüller B and Kurz T. 8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity. ChemMedChem. 2019 Feb 19; 14(4): 501-511.


Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT and Cooper MA. Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry.  2018 Dec 27; 24(60): 10078-10090.

Senadeera SPD, Robertson LP, Duffy S, Wang Y, Avery VM and Carroll A. β-Triketone-Monoterpene Hybrids from the Flowers of the Australian Tree Corymbia intermedia. Journal of Natural Products. 2018 Nov 26; 81(11): 2455-2461.

Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould A, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR and Tilley L. Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. Journal of Medicinal Chemistry. 2018 Nov 21; 61(22): 10053-10066.

Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT and Hansen FK. One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European Journal of Medicinal Chemistry. 2018 Oct 5; 158: 801-813.

Duffy S and Avery VM. Plasmodium falciparum In Vitro Culture – The Highs and Lows. Trends in Parasitology. [Invited opinion] 2018 Oct; 34(10): 812-813.

Butler NM, Hendra R, Bremner JB, Willis AC, Lucantoni L, Avery VM and Keller PA. Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro-oxazocinodiindoles. Organic & Biomolecular Chemistry. 2018 Aug 2018 Aug 22; 16(33): 6006-6016.

Chellan P, Avery VM, Duffy S, Triccas JA, Nagalingam G, Tam C, Cheng LW, Liu J, Land KM, Clarkson GJ, Romero-Canelón I and Sadler PJ. Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance. Chemistry – A European Journal. 2018 July; 24(40): 10078-10090.

Senadeera SPD, Lucantoni L, Duffy S, Avery VM and Carroll AR. Antiplasmodial β-Triketone–Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana. Journal of Natural Products. 2018 Jul 27;81(7):1588-1597.

Duffy S and Avery VM. Routine in vitro culture of Plasmodium falciparum: experimental consequences? Trends in Parasitology. [Invited review] 2018 July; 34(7): 564-575.

Buedenbender L, Robertson LP, Lucantoni L, Avery VM, Kurtböke Dİ, and Carroll AR. HSQC-TOCSY Fingerprinting-Directed Discovery of Antiplasmodial Polyketides from the Marine Ascidian-Derived Streptomyces sp. (USC-16018). Marine Drugs. 2018 May 30; 16(6): 189.

Kumar R, Duffy S, Avery VM, Carroll AR, Davis RA. Microthecaline A, a Quinoline Serrulatane Alkaloid Isolated from the Roots of the Australian Desert Plant Eremophila microtheca. Journal of Natural Products. 2018 Apr 27; 81(4): 1079-1083.

Buedenbender L, Habener LJ, Grkovic T, Kurtböke Dİ, Duffy S, Avery VM and Carroll AR. HSQC–TOCSY Fingerprinting for Prioritization of Polyketide- and Peptide-Producing Microbial Isolates. Journal of Natural Products. 2018 Apr 27; 81(4): 957-965.

Sykes ML and Avery VM. 3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition.  Scientific Reports. 2018 Mar 20; 8(1): 4901.

Lovitt CJ,  Shelper TB and  Avery VM. Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins. BMC Cancer. 2018 Jan 6; 18(1): 41.


Robertson LP, Duffy S, Wang Y, Wang D,  Avery VM and  Carroll AR. Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana. Journal of Natural Products. 2017 Dec 22; 80(12): 3211-3217.

Zulfiqar B, Jones AJ, Sykes ML, Shelper TB, Davis RA, and Avery VM. Screening a Natural Product-Based Library against Kinetoplastid Parasites. Molecules. 2017 Oct 12; 22(10): E1715.

Zulfiqar B, Shelper TB and Avery VM. Leishmaniasis drug discovery: recent progress and challenges in assay development. Drug Discovery Today. [Review] Oct 2017; 22(10): 1516-153.

Stenzel K, Chua MJ, Duffy S, Antonova-Koch Y, Meister S, Hamacher A, Kassack MU, Winzeler E, Avery VM, Kurz T, Andrews KT and  Hansen FK. Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity. ChemMedChem. 2017 Oct 9; 12(19): 1627-1636.

Kumar R, Duffy S, Avery VM and Davis RA. Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid. Bioorganic & Medicinal Chemistry Letters. 2017 Sep 1; 27(17): 4091-4095.

Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler EA, Egan TJ, Hoffman SL, Avery VM and Fidock DA. Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature Microbiology. 2017 Aug 14; 2: 1403–1414.

Duffy S, Sykes ML, Jones AJ, Shelper TB, Simpson M, Lang R, Poulsen SA, Sleebs BE and Avery VM. Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery. Antimicrobial Agents and Chemotherapy. 2017 Aug 24; 61(9): e00379-17.

Duffy S and Avery VM. Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle. International Journal of Parasitology: drugs and drug resistance. 2017 July 15; 7(3): 295-302.

Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler EA, Avery VM, Mordmüller B, Wittlin S and Kurz T.3-Hydroxy-N‘-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. Journal of Medicinal Chemistry. 2017 July 27; 60(14): 6036-6044.

Marco M, Deyou T, Gruhonjic A, Holleran J, Duffy S, Heydenreich M,  Firtzpatrick PA, Landberg G, Koch A, Derese S, Pelletier J,  Avery VM, Erdélyi M and Yenesew A. Pterocarpans and isoflavones from the roots of Millettia micans and of Millettia dura. Phytochemistry Letters. 2017; 21: 216-222.

Senadeera SPD, Duffy S, Avery VM and Carroll AR. Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana. Bioorganic & Medicinal Chemistry Letters. 2017 June 1; 27(11): 2602-2607.

Weidner T,  Lucantoni L,  Nasereddin A, Preu L,  Jones PG, Dzikowski R, Avery VM and Kunick C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytes stages. Malaria Journal. 2017 May 15; 16(1): 192.

Lucantoni L, Loganathan S and Avery VM. The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes. Scientific Reports. 2017 Apr 5; 7: 45992.

Kaemmerer E, Rodriguez Garzon T, Lock A, Lovitt C and Avery VM. Innovative in vitro models for breast cancer drug discovery. Drug Discovery Today: Disease Models. [Invited review] 2017 March 18; 21: 11-16.

Atilaw Y, Duffy S, Heydenreich M, Muiva-Mutisya L, Avery VM, Erdelyi M* and Yenesew A.* Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata. Molecules. 2017 Feb 20; 22(2): 318.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF and Sleebs BE. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. Journal of Medicinal Chemistry. 2017 Feb 9; 60(3): 1171-1188.

Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP and Lanzer M. SC83288 is a clinical development candidate for the treatment of severe malaria. Nature Communications. 2017 Jan 31; 8: 14193.

Nyandoro SS, Munissi JE, Gruhonjic A, Duffy S, Pan F, Puttreddy R, Holleran JP, Fitzpatrick PA, Pelletier J, Avery VM, Rissanen K and Erdélyi M. Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves. Journal of Natural Products. 2017 Jan 27; 80(1): 114-125.


Buedenbender L, Grkovic T, Duffy S, Ipek Kurtböke D, Avery VM and Carroll AR. Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp. Tedrahedron Letters. 2016 Dec 28; 57(52): 5893-5895.

Fletcher S, Lucantoni L,  Sykes ML,  Jones AJ, Holleran JP,  Saliba KJ and Avery VM. Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway. Parasites & Vectors. 2016 Nov 17; 9(1): 589.

Baragaña B, Norcross NR, Wilson C, Porzelle A, Hallyburton I, Grimaldi R, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Wyatt PG, Delves MJ, Meister S, Duffy S, Avery VM, Winzeler EA, Sinden RE, Wittlin S, Frearson JA, Gray DW, Fairlamb AH, Waterson D, Campbell SF, Willis P, Read KD and Gilbert IH. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of Medicinal Chemistry. 2016 Nov 10; 59(21): 9672-9685.

Russell S, Rahmani R, Jones AJ, Newson H, Neilde K, Cotillo I, Rahmani Khajouei M, Ferrins L, Qureishi S, Nguyen N, Martínez-Martínez MS, Weaver DF, Kaiser M, Riley J, Thomas J, De Rycker M, Read KD, Flematti GR, Ryan E, Tanghe S, Rodriguez A, Charman SA, Kessler A, Avery VM, Baell JB and Piggott MJ. Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. Journal of Medicinal Chemistry. 2016 Nov 10; 59(21): 9686-9720.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S and Todd MH. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. ACS Central Science. 2016 Oct 26; 2(10): 687-701.

Bhatia M, Lovitt CJ, Raninga PV, Avery VM, Di Trapani G and Tonissen KF. Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment. European Journal of Cell Biology. 2016 Oct; 95(10): 378-388.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail J, Mitasev B, Moss EL, Sayes M, VanGessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA and Schreiber SL. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Sep 7; 538(7625): 344-349.

Lovitt CJ, Hilko DH, Avery VM and Poulsen SA. Development of ethynyl-2′-deoxyuridine chemical probes for cell proliferation. Bioorganic & Medicinal Chemistry.  2016 Sep 15; 24(18):4272-4280.

Shelper TB, Lovitt CJ and Avery VM. Assessing Drug Efficacy in a Miniaturized Pancreatic Cancer In Vitro 3D Cell Culture Model. ASSAY and Drug Development Technologies. [Special edition] 2016 Sep; 14(7): 367-380.

Lovitt CJ,  Shelper TB and  Avery VM. Cancer drug discovery: recent innovative approaches to tumor modeling. Expert Opinion On Drug Discovery. [Invited review]. 2016 Sep; 11(9): 885-894.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D’Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T and Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS Pathogens. 2016 Jul 28; 12(7): e1005763.

Scott FJ, Khalaf AI, Duffy S, Avery VM and Suckling CJ. Selective anti-malarial minor groove binders. Bioorganic & Medicinal Chemistry Letters. 2016 Jul 15; 26(14): 3326-3329.

Stoessel D, Nowell CJ, Jones AJ, Ferrins L, Ellis KM, Riley J, Rahmani R, Read KD, McConville MJ, Avery VM, Baell JB and Creek DJ. Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide. MetabolomicsJuly 2016. 12:126.

Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, Sanz L, Jiménez-Díaz B, Angulo-Barturen I, Ferrer S, Martínez MS, Gamo FJ, Frearson JA, Gray DW, Fairlamb AH, Winzeler EA, Waterson D, Campbell SF, Willis P, Read KD and Gilbert IH. Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials. Journal of Medicinal Chemistry. 2016 Jul 14; 59(13): 6101-6120.

Duffy S, Loganathan S, Holleran JP and Avery VM. Large scale production of Plasmodium falciparum gametocytes for malaria drug discovery. Nature Protocols. 2016 May; 11(5): 976-992.

Lucantoni L, Fidock DA and Avery VM. Luciferase-Based, High-Throughput Assay For Screening And Profiling Transmission-Blocking Compounds Against Plasmodium falciparum Gametocytes. Antimicrobial Agents and Chemotherapy. 2016 Mar 25; 60(4): 2097-2107.

Scott FJ, Khalaf AI, Giordani F, Wong PE, Duffy S, Barrett M, Avery VM and Suckling CJ. An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry. 2016 Mar 29; 116: 116-125.

Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powel AK, Avery VM, McGowan S and Scammells PJ. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry. 2016 Mar 3; 110: 43-64.

Jones AJ, Kaiser M and Avery VM. Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis. Antimicrobial Agents and Chemotherapy. 2016 Mar; 60(3): 1859-1861.


Sykes ML and Avery VM. Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosma cruzi amastigotes. International Journal for Parasitology: Drugs and Drug Resistance. 2015 Dec 1; 5(3): 215-228.

Deyou T, Gumula I, Pan F, Gruhonjic A, Mumo M, Holleran J, Duffy S, Fitzpatrick P, Heydenreich M, Landberg G, Derese S, Avery VM, Rissanen K, Erdelyi M and Yenesew A. Rotenoids, Flavonoids and Chalcones from the Root Bark of Millettia usaramensis. Journal of Natural Products. 2015 Dec 24; 78(12): 2932-2939.

Jones AJ and Avery VM. Future treatment options for human African trypanosomiasis. Expert Review of Anti-infective Therapy. [Invited review] 2015 Dec; 13(12): 1429-1432.

Lucantoni L, Silvestrini F, Signore M, Siciliano G, Eldering M, Dechering KJ, Avery VM and P Alano. A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds. Scientific Reports. 2015 Nov 10; 5: 16414.

Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA and Baell JB. 6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors. Journal of Medicinal Chemistry. 2015 Sept 10; 58(17): 6753-6765.

Duez J, Hollerand JP, Ndour PA, Pionneau C, Diakité S, Roussel C, Dussiot M, Amireault P, Avery VM and Buffet PA. Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method. Transfusion Clinique et Biologique. [Invited review] 2015 Aug; 22(3): 151-157.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN and Charman SA. A long-duration dihydrooroate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science: Translational Medicine. 2015 Jul 15; 7(296): 296ra111.

Duez J, Holleran JP, Ndour PA, Loganathan S, Amireault P, Français O, El Nemer W, Le Pioufle B, Amado IF, Garcia S, Chartrel N, Le Van Kim C, Lavazec C, Avery VM and Buffet PA. Splenic Retention of Plasmodium falciparum Gametocytes To Block the Transmission of Malaria. Antimicrobial Agents and Chemotherapy. 2015 Jul; 59(7): 4206-4214.

Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Adams TS and Andrews KT. Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. International Journal for Parasitology: Drug and Drug Resistance. 2015 Jun 20; 5(3): 117-26.

Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Bolscher JM, Woodland A, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Belén Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW,  Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD and Gilbert IH. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 June 18; 522(7556): 315-320.

Lovitt CJ, Shelper TB and Avery VM. Evaluation of chemotherapeutics in a three-dimensional breast cancer model. Journal of Cancer Research and Clinical Oncology. 2015 May; 141(5): 951-959.

Kumar R, Sadowski MC, Levrier C, Nelson CC, Jones AJ, Holleran JP, Avery VM, Healy PC and Davis RA. Design and Synthesis of a Screening Library Using the Natural Product Scaffold, 3-Chloro-4-hydroxyphenylacetic Acid. Journal of Natural Products.  2015 April 24; 78(4): 914-918.

Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Santos Martinez M, Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ, Sinden RE, Fuchter MJ and Scherf A. Histone Methyltransferase Inhibitors are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans. Antimicrobial Agents and Chemotherapy. 2015 Feb; 59(2): 950-959.

Helgren TR, Sciotti RJ, Lee P, Duffy S, Avery VM, Igbinoba O, Akoto M and Hagen TJ. The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs. Bioorganic & Medicinal Chemistry Letters. 2015 Jan 15; 25(2): 327-332.

Manos-Turvey A, Watson EE, Sykes ML, Jones AJ, Baell JB, Kaiser M, Avery VM and Payne RJ. Synthesis and Evaluation of Phenoxymethylbenzamide Analogues as Anti-Trypanosomal Agents. MedChemComm. 2015; 6(3): 403-406.


Belén Jiménez-Díaz M, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O’Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Santos Martinez M, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo F-J, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM and Guy RK. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. PNAS. 2014 Dec 16; 111(50): E5455-5462.

Davis RA, Beattie KD, Xu M, Yang X, Yin S, Holla H, Healy PC, Sykes M, Shelper T, Avery VM, Elofsson M, Sundin C and Quinn RJ.  Solving the Supply of Resveratrol Tetramers from Papua New Guinean Rainforest Anisoptera Species That Inhibit Bacterial Type III Secretion Systems. Journal of Natural Products.  2014 Dec 26; 77(12): 2633-2640.

Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ, Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, Stasiak M, Charman SA, Angulo-Barturen I, Ferrer S, Belén Jiménez-Díaz M, Martínez MS, Gamo FJ, Avery VM, Ruecker A, Delves M, Kirk K, Berriman M, Kortagere S, Burrows J, Fan E and Bergman LW. Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. Nature Communications. 2014 Nov 25; 5: 5521.

Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ and McGowan S. Two-pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. Journal of Medicinal Chemistry. 2014 Nov 13; 57(21): 9168-9183.

Leven M, Held J, Duffy S, Tschan S, Sax S, Kamber J, Frank W, Kuna K, Geffken D, Siethoff C, Barth S, Avery VM, Wittlin S, Mordmüller B and Kurz T. Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N’-arylidenepropane-hydrazonamides: A new class of antiplasmodial compounds. Journal of Medicinal Chemistry. 2014 Oct 9; 57(19): 7971-7976.

Fletcher S and Avery VM. A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway. Malaria Journal. 2014 Aug 31; 13(1): 343.

Ramachandran S, Hameed P S, Srivastava A, Shanbhag G,  Morayya S, Rautela N, Awasthy D, Kavanagh S, Bharath S, Reddy J, Panduga V, Prabhakar KR, Saralaya R, Nanduri R, Raichurkar A, Meenasinikai S, Achar V, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Waterson D, Lee MC, Coburn-Flynn O, Fidock DA, Iyer PS, Narayanan S, Hosagrahara V and Sambandamurthy VK. N-aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds. Journal of Medicinal Chemistry. 2014 Aug 14; 57(15): 6642-6652.

Ferrins L,  Gazdik M,  Rahmani R,  Varghese S,  Sykes ML, Jones A, Avery VM, White KL,  Ryan E, Charman SA, Kaiser M, Bergstrom CA and Baell JB. Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei. Journal of Medicinal Chemistry. 2014 Aug 14; 57(15): 6393-6402.

Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ,  Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T and Andrews KT. Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules. Antimicrobial Agents and Chemotherapy. 2014 Jul; 58(7): 3666-3678.

Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jimenez-Diaz MB, Martinez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK and Ramachandran S.  Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial agents. Journal of Medicinal Chemistry. 2014 July 10; 57(13): 5702-5713.

Lawer A, Tai J, Jolliffe KA, Fletcher S, Avery VM and Hunter L. Total synthesis and antiplasmodial activity of pohlianin C and analogues. Bioorganic & Medicinal Chemistry Letters. 2014 15 June; 24(12): 2645-2647.

Lovitt CJ, Shelper TB and Avery VM. Advanced Cell Culture Techniques for Cancer Drug Discovery. Biology. [invited review] 2014 May 30; 3(2): 345-367.

Avery VM, Bashyam S, Burrows JN, Duffy S, Papadatos G,  Puthukkuti S, Sambandan Y, Singh S, Spangenberg T, Waterson D and Willis P. Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparumMalaria Journal.  2014 27 May; 13(1): 190.

Hansen FK, Sumanadasa SDM, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A,  Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT and Kurz T. Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages. European Journal of Medicinal Chemistry. 2014 May 22; 82C: 204-213.

Lotharius J, Gamo-Benito FJ, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, Parkinson T, Viswanath P, Bandodkar B, Rautela N, Bharath S, Duffy S, Avery VM, Möhrle JJ, Guy RK and Wells T. Repositioning: the fast track to new anti-malarial medicines? Malaria Journal. 2014 April 14; 13: 143.

Rashad AA, Jones AJ, Avery VM, Baell J and Keller PA. Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma bruceiACS Medicinal Chemistry Letters. 2014 March 10; 5(5): 496-500.

Le Manach C, Gonzalez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ and Chibale K. Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1. Journal of Medicinal Chemistry.  2014 March 27; 57(6): 2789-2798.

Hansen FK, Skinner-Adams TS, Duffy S, Marek L, Sumanadasa SD, Kuna K, Held J, Avery VM, Andrews KT and Kurz T. Synthesis, Antimalarial Properties and SAR Studies of Alkoxyurea-Based HDAC Inhibitors. ChemMedChem. [Invited review] 2014 March; 9(3): 665-670.

Neve JE, Wijesekera HP, Duffy S, Jenkins ID, Ripper JA, Teague SJ, Campitelli M, Garavelas A, Nikolakopoulos G, Le PV, de A Leone P, Pham NB, Shelton P, Fraser N, Carroll AR, Avery VM, McCrae C, Williams N and Quinn RJ. Euodenine A: A small-molecule agonist of human TLR4. Journal of Medicinal Chemistry. 2014 Feb 27; 57(4): 1252-1275.

González Cabrera D, Le Manach C, Douelle F, Younis Y, Feng T-S, Paquet T, Nchinda AT, Street LJ,  Taylor D, de Kock C, Wiesner L, Duffy S, White KL, Zabiulla K, Sambandan Y, Bashyam S, Waterson D, Witty MJ, Charman SA, Avery VM, Wittlin S and Chibale K. 2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents. Journal of Medicinal Chemistry. 2014 Feb 13; 57(3): 1014-1022.


Lucantoni L, Duffy S, Adjalley SH, Fidock DA and Avery VM. Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes, Using a Luciferase-based High-Throughput Assay. Antimicrobial Agents and Chemotherapy. 2013 Dec; 57(12): 6050-6062.

Hoque Md T, * Windus LC, * Lovitt CJ and Avery VM. PCa Analyser: A 2D-Image Analysis Based Module for Effective Determination of Prostate Cancer Progression in 3D Culture. PLoS One. 2013 Nov 20; 8(11): e79865. * Equal first author.

Duffy S and Avery VM. Identification of inhibitors of Plasmodium falciparum gametocyte development. Malaria Journal. 2013 Nov 11; 12(1): 408.

Kiss DL, Windus LCE and Avery VM. Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D Culture. Cytokine. 2013 Oct; 64(1): 122-130.

Jones AJ, Grkovic T, Sykes ML and Avery VM. Trypanocidal Activity of Marine Natural Products.  Marine Drugs[invited review] 2013 Oct 22; 11(10): 4058-4082.

Stevenson G, Yong S, Fechner G, Neve J, Lock A and Avery VM. Solid-Phase Synthesis of Biotin-S-Farnesyl-L-Cysteine, a surrogate substrate for Isoprenylcysteine Carboxylmethyltransferase (ICMT). Bioorganic & Medicinal Chemistry Letters2013 Oct 15; 23(20): 5671-5673.

Avery V, Buckner F, Baell J, Fairlamb A, Michels PA and Tarleton R. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease. Future Medicinal Chemistry.  [invited review] 2013 Oct; 5(15): 1709-1718.

Sykes ML and Avery VM. Approaches to Protozoan Drug Discovery: Phenotypic Screening. Journal of Medicinal Chemistry[invited review] 2013 Aug 8; 56(20): 7727-7740.

Davis RA, Duffy S, Fletcher S, Avery VM and RJ Quinn. Thiaplakortones A-D: Antimalarial Thiazine Alkaloids from the Australian Marine Sponge Plakortis litaJournal of Organic Chemistry.  2013 Oct 4; 78(19): 9608-9613.

Windus LCE, Glover TT and Avery VM. Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of Prostate Cancer. Molecular Cancer 2013 Sept 30; 12(1): 112.

Lovitt CJ*, Shelper TB* and Avery VM. Miniaturized three-dimensional cancer model for drug evaluation. ASSAY and Drug Development Technologies. September 1 2013, 11(7): 435-448.  * Equal first author.

Teguh S, Klonis N, Duffy S, Lucantoni L, Avery VM, Hutton C, Baell J and Tilley L. Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity. Journal of Medicinal Chemistry. 2013 Aug 8; 56(15): 6200-6215.

Ferrins L, Rahmani R, Sykes M,  Jones A, Avery VM, Teston E,  Almohaywi B, Yin J, Smith J, Hyland C, White K, Ryan E, Campbell M, Charman S, Kaiser M and Baell J. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European Journal of Medicinal Chemistry.2013 May 16; 66C: 450-465.

Jones A and Avery VM. Whole-organism high-throughput screening against Trypanosoma brucei brucei. Expert Opinion on Drug Discovery. [invited review] 2013 May; 8(5): 495-507.

Nilsen A, LaCrue A, White KL, Forquer IP, Cross RM, Marfurt J, Mather M, Delves MJ, Shackleford DM, Saenz F, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Xu Kelly J, Facino Sebayang B, Zeeman A-M, Noviyanti R, Sinden RE, HM Kocken C, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Javier Gamo Benito F, Bathurst I, Burrows J, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R and  Riscoe MK. Quinolone-3-Diarylethers: a new class of antimalarial drug.  Science Translational Medicine. 2013 Mar 20; 5(177): 177ra37.

Carroll AR, Avery VM, Duffy S, Forster PI and Guymer GP. Watsonianone A – C, anti-plasmodial b-triketones from the Australian Tree, Corymbia watsoniana. Organic & Biomolecular Chemistry. 2013 Jan 21; 11(3): 453-458.


Buckner FS, Waters NC and Avery VM. Recent Highlights in anti-protozoan drug development and resistance research. International Journal for Parasitology: Drugs and Drug Resistance. 2012 Dec; 2: 230-235.

Lucantoni L and Avery VM. Whole cell in vitro screening for gametocytocidal compounds. Future Medicinal Chemistry. 2012 Dec; 4(18): 2337-2360.

Sykes ML, Baell JB, Kaiser M, Chatelain E, Ganame D, Ioset JR and Avery VM. Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei BS427 by a Whole Cell Viability Based HTS Campaign. PLOS Neglected Tropical Diseases. 2012 Nov; 6(11): e1896.

Windus LC, Kiss DL, Glover T and Avery VM. In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer. Experimental Cell Research. 2012 Nov 15; 318 (19): 2507-2519.

Feng Y, Davis RA, Sykes ML, Avery VM and Quinn RJ. Iotrochamides A and B, antitrypanosomal compounds from the Australian Marine Sponge Iotrochota sp.   Bioorganic & Medicinal Chemistry Letters. 2012 July 15; 22(14): 4873-4876.

Davis RA, Buchanan MS, Duffy S, Avery VM, Charman SA, Charman WN, White KL, Shackleford DM, Edstein MD, Andrews KT, Camp D and Quinn RJ. Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp.  Journal of Medicinal Chemistry. 2012 Jun 28; 55(12): 5851-5858.

Carroll AR, Nash BD, Duffy S and Avery VM. Albopunctatone, an Antiplasmodial Anthrone-Anthraquinone from the Australian Ascidian Didemnum albopunctatum. Journal of Natural Products. 2012 June 22; 75(6): 1206-1209.

Carroll AR, Wild SJ, Duffy S and Avery VM.  Kororamide A, a new tribrominated indole alkaloid from the Australian bryozoan Amathia tortuosa. Tetrahedron Letters. 2012 June 6; 53(23): 2873-2875.

Edlin CD, Morgans G, Winks S, Duffy S, Avery VM, Wittlin S, Waterson D, Burrows J and Bryans J. Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit to Lead Chemistry. ACS Medicinal Chemistry Letters. 2012 May 28; 3(7): 570-573.

Xu M, Davis RA, Feng Y, Sykes ML, Shelper T, Avery VM, Camp D and Quinn RJ. Ianthelliformisamines A-C: Antibacterial Bromotyrosine-derived Metabolites from the Marine Sponge Suberea ianthelliformisJournal of Natural Products. 2012 May 25; 75(5): 1001-1005.

Younis Y, Douelle F, Feng T-S, González Cabrera D, Le Manach C, Nchinda AT, Duffy S,  White  KL, Shackleford DM, Morizzi J,  Mannila J,  Kasiram Katneni KL,  Bhamidipati R,  Zabiulla KM,  Joseph JT,  Bashyam S,  Waterson D, Witty MJ, Hardick D, Wittlin S, Avery V, Charman SA and Chibale K. 3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential. Journal of Medicinal Chemistry. 2012 Apr 12; 55(7): 3479-3487.

Duffy S and Avery VM. Development and Optimization of a Novel 384-Well Anti-malarial Imaging Assay Validated for High-Throughput Screening. American Journal of Tropical Medicine & Hygiene. 2012 Jan; 86(1): 84-92.

Hiranrat A, Mahabusarakam W, Carroll AR, Duffy S and Avery VM. Tomentosones A and B, Hexacyclic Phloroglucinol Derivatives from the Thai Shrub Rhodomyrtus tomentosa. Journal of Organic Chemistry. 2012 Jan 6; 77(1): 680-683.


Yu M, Price JR, Jensen P, Lovitt CJ, Shelper T, Duffy S, Windus LC, Avery VM, Rutledge PJ and Todd MH. Copper, Nickel, and Zinc Cyclam-Amino Acid and Cyclam-Peptide Complexes may be Synthesized with “Click” Chemistry and Are Noncyctotoxic. Inorganic Chemistry. 2011 Dec 19; 50(24): 12823-12835.

Davis RA, Sykes ML, Avery VM, Camp D and Quinn RJ. Convolutamines I and J, anti-trypanosomal alkaloids from the bryozoan Amathia tortusaBioorganic & Medicinal Chemistry. 2011 Nov 15; 19(22): 6615-6619.

Martin F, Grkovic T, Sykes ML, Shelper T, Avery VM, Camp D, Quinn RJ and Davis RA. Alkaloids from the Chinese Vine Gnetum montanum. Journal of Natural Products. 2011 Nov 28; 74(11): 2425-2430.

Adeyemi OS, Sykes ML, Akanji MA and Avery VM. Anti-trypanosomal and cytotoxic activity of ethanolic extracts of Psidium guajava leaves in Alamar Blue based assays. Veterinarski Arhiv. 2011; 81(5): 623-633.

Yang X, Feng Y, Duffy S, Avery VM, Camp D, Quinn RJ and Davis RA. A New Quinoline Epoxide from the Australian Plant Drummondita calidaPlanta Medica2011 Sep; 77(14): 1644-1647.

Yin S, Davis RA, Sykes  ML, Shelper T, Avery VM, Elofsson M, Sundin C and Quinn RJ. Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp. Organic & Biomolecular Chemistry. 2011 Sep 9; 9(19): 6755-6760.

Carroll AR, Duffy S, Sykes M and Avery VM. Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni. Organic & Biomolecular Chemistry. 2011 Jan 21; 9(2): 604-609.


Carroll AR, Duffy S and Avery VM. Aplidiopsamine A, an antiplasmodial alkaloid from the temperate Australian ascidian, Aplidiopsis confluata. Journal of Organic Chemistry. 2010 Dec 3; 75(23): 8291-8294.

Yin S, Sykes ML, Davis RA, Shelper T, Avery VM, Camp D and Quinn RJ. New galloylated flavanonols from the Australian plant Glochidion sumatranum. Planta Medica. 2010 Nov; 76(16): 1877-1881.

Ban K, Duffy S, Khakham Y, Avery VM, Hughes A, Montagnat O, Katneni K, Ryan E and Baell JB. 3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.  Bioorganic & Medicinal Chemistry Letters. 2010 Oct 15; 20(20): 6024-6029.

Fernandez LS, Sykes ML, Andrews KT and Avery VM. Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia. International Journal of Antimicrobial Agents. 2010 Sep; 36(3): 275-279.

Feng Y, Davis RA, Sykes ML, Avery VM, Camp D and Quinn RJ. Pseudoceratinazole A: a novel bromotyrosine alkaloid from the Australian sponge Pseudoceratina sp. Tetrahedron Letters. 2010; 51: 4847–4850.

Hoque Md T, Madhu Chetty M, Lewis A, Sattar A and Avery VM. DFS generated pathways in GA crossover for protein structure prediction. Neurocomputing. 2010; 73: 2308–2316.

Nhu D, Duffy S, Avery VM, Hughes A and Baell JB. Antimalarial 3-Arylamino-6-benzylamino-1, 2, 4, 5-tetrazines. Bioorganic & Medicinal Chemistry Letters. 2010 Aug 1; 20(15): 4496-4498.

Davis RA, Demirkiran O, Sykes ML, Avery VM,  Suraweera L, Fechner GA and Quinn RJ. 7′, 8′-Dihydroobolactone, a trypanocidal-pyrone from the rainforest tree Cryptocarya obovata.  Bioorganic & Medicinal Chemistry Letters. 2010 Jul 15; 20(14): 4057- 4059.

Guiguemde W.A, Anang A, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson D, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson E, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley P L, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal P L, DeRisi JL, Sullivan Jr D J, Lazo JS, Roos D S, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM and Guy RK. Chemical Genetics of Plasmodium falciparum. Nature. May 20, 2010; 465(7296): 311-315.

Yang X, Davis RA, Buchanan MS, Duffy S, Avery VM, Camp D and Quinn RJ. Antimalarial Bromotyrosine Derivatives from the Australian Marine Sponge Hyattella sp. Journal of Natural Products. 2010; 73: 985–987.

Feng Y, Davis RA, Sykes ML, Avery VM, Carroll AR, Camp D and Quinn RJ. Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatumTetrahedron Letters. 2010; 51: 2477-2479.

Feng Y, Davis RA, Sykes ML, Avery VM, Camp D and Quinn RJ. Antitrypanosomal Cyclic Polyketetide Peroxides from the Australian Marine Sponge Plakoritis sp. Journal of Natural Products. Apr 23 2010; 73(4): 716-719.

Davis RA, Duffy S, Avery VM, Camp D, Hooper JNA and Quinn RJ. (+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp. Tetrahedron Letters 2010; 51(4): 583-585.

Hoque Md T and Avery VM. Novel Strategies to speed-Up Query Response. Research Journal of Information Technology. 2010; 2(1): 11-20.


Sykes ML and Avery VM. A Luciferase Based Viability Assay for ATP Detection in 384-Well Format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei Bloodstream Form 427. Parasites & Vectors. 2009 Nov12; 2(1): 54.

Sykes ML and Avery VM. Development of an Alamar Blue™ Viability Assay in 384 well format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei BS427. American Journal of Tropical Medicine & Hygiene. 2009 Oct; 81(4): 665-674.

Buchanan MS, Davis RA, Duffy S, Avery VM and Quinn RJ. Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras. Journal of Natural Products. 2009 Aug; 72(8): 1541-1543.

Buchanan S, Carroll AR, Wessling D, Jobling M, Avery VM, Davis RA, Feng Y, Hooper JNA and Quinn RJ. Clavatadines C – E Guanidine Alkaloids from the Australian Sponge Suberea clavataJournal of Natural Products. 2009 Aug; 72(5): 973–975.

Mueller D, Davis RA, Duffy S, Avery VM, Camp D and Quinn RJ. Antimalarial Activity of Azafluorenone Alkaloids from the Australian Tree Mitrephora diversifolia. Journal of Natural Products. 2009 Aug; 72(8): 1538-1540.

Kiss DL, Longden J, Fechner GA and Avery VM. The functional antagonist Met-RANTES: a modified agonist that induces differential CCR5 trafficking. Cellular & Molecular Biology Letters. 2009 May; 14(4): 537-547.

Carroll AR and Avery VM Leptoclinidamines A#C, Indole Alkaloids from the Australian Ascidian, Leptoclinides durusJournal of Natural Products. 2009 Apr; 72(4): 696-699.

Carroll AR, Duffy S and Avery VM. Citronamide A and B, Tetrapeptides from the Australian Sponge, Citronia astraJournal of Natural Products. 2009 Apr; 72(4): 764-768.

Davis RA, Fechner GA, Sykes ML, Garavelas A, Pass AM, Carroll AR , Addepalli R, Avery VM, Hooper JNA and Quinn RJ. (-)-Dibromophakallin: An alpha2β Adenoceptor Agonist isolated from the Australian marine sponge, Acanthella costata. Bioorganic & Medicinal Chemistry. 2009 Mar 15; 17(6): 2497-2500.

Davis RA, Barnes EC, Longden J, Avery VM and Healy PC. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum. Bioorganic & Medicinal Chemistry. 2009 Feb 1; 17(3): 1387-1392.

Fernandez LS, Buchanan MS, Carroll AR, Jiang Y Feng, Quinn RJ and Avery VM. Flinderoles A#C: Novel anti-malarial bis-indole alkaloids from Flindersia sp. Organic Letters. 2009 Jan 15; 11(2): 329-332.


Fernandez LS, Jobling MF, Andrews KT and Avery VM. Anti-malarial Activity of Natural Product Extracts from Tropical Queensland and Papua New Guinea. Phytotherapy Research. 2008 Oct; 22: 1409-1412.

Buchanan MS, Carroll AR , Fechner GA , Boyle A , Simpson M, Addepalli R, Avery V M, Forster PI, Guymer GP, Cheung T, Chen H and Quinn RJ. Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx. Phytochemistry. 2008 Jun; 69(9): 1886-1889.

Buchanan MS, Carroll AR, Wessling D, Jobling M, Avery VM, Davis RA, Feng Y, Xue Y, Oster L, Fex T, Deinum J, Hooper JNA and Quinn RJ. Clavatadine A, A Natural Product with Selective recognition and irreversible inhibition of Factor Xia. Journal of Medicinal Chemistry. 2008 Jun 26; 51(12): 3583-3587.

Buchanan MS, Carroll AR, Fechner GA, Boyle A, Simpson M, Addepalli R, Avery VM, Hooper JNA, Cheung T, Chen H and Quinn RJ. Apylsamine 6, an Alkaloid Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp. Journal of Natural Products. 2008 Jun; 71(6): 1066-1067.

Davis RA, Longden J, Avery VM and Healy PC. The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C.  Bioorganic & Medicinal Chemistry Letters. 2008 May 1; 18(9): 2836-2839.

Cogger VC, Arias IM, Warren A, McMahon A, Kiss DL, Avery VM and Le Couteur D G. The response of fenestrations, actin and calveolin-1 to vascular endothelial growth factor in SKHep1 cells (a liver sinusoidal endothelial cell line). American Journal of Physiology (Gastrointest Physiol Liver). 2008 May 14; 295: 137-145.

Davis RA, Simpson MM, Nugent RB, Carroll AR, Avery VM, Rali T, Chen H, Qurallo B and  Quinn RJ. Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Journal of Natural Products. 2008 Mar; 71(3): 451-452.

Feng Y, Carroll RA, Pass DM, Archbold JK, Avery VM and Quinn RJ. Polydiscamides B#D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists. Journal of Natural Products. 2008 Jan; 71(1): 8-11.


Camp D, Avery VM, Street I and Quinn RJ. Progress toward establishing an open access molecular screening capability in the Australasian region. ACS Chemical Biology. 2007 Dec 21; 2(12): 764-767.

Buchanan MS, Carroll AR, Fechner GA, Boyle A, Simpson MM, Addepalli R, Avery VM, Hooper JNA, Su N, Chen H and Quinn RJ. Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Bioorganic & Medicinal Chemistry Letters. 2007 Dec 15; 17(24): 6860-6863.

Mitchell JK, Pitcher D, McArdle BM, Alnefeld T, Duffy S, Avery VM and Quinn RJ. Identifying common metalloproteinase inhibitors by protein fold type, using Fourier Transform Mass spectroscopy. Bioorganic & Medicinal Chemistry Letters. 2007 Dec 1; 17(23): 6521-6524.

Buchanan MS, Carroll AR, Addepalli R, Avery VM, Hooper JN and Quinn RJ. Niphatoxin C, a Cytotoxic Trypyridine Alkaloid from Callyspongia sp.  Journal of Natural Products. 2007 Dec; 70(12): 2040-2041.

Buchanan MS, Carroll AR, Addepalli R, Avery VM, Hooper JNA and Quinn RJ. Psammaplysenes C and D, Cytotoxic Alkaloids from Psammoclemma sp. Journal of Natural Products. 2007 Nov; 70(11): 1827-1829.

Feng Y, Carroll AR, Addepalli R, Fechner GA, Avery VM and Quinn RJ. Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.  Journal of Natural Products. 2007 Nov; 70(11): 1790-1792.

Davis RA, Carroll AR, Duffy S, Avery VM, Guymer GP, Forster PI and Quinn RJ. Endiandran A, a Potent Glucocorticoid Receptor Binding Modulator Isolated from the Australian Plant Endiandra anthropophagorum. Journal of Natural Products. 2007; 70: 1118-1121.

Buchanan MS, Carroll AR, Addepalli R, Avery VM, Hooper JNA and Quinn RJ. Natural Products, Stylissadines A and B, Specific Antagonists of the P2X7 Receptor, an Important Inflammatory Target.  Journal of Organic Chemistry. 2007; 72(7): 2309-2317.

Book Chapters:

Vicky M. Avery, David Camp, Anthony R. Carroll, Ian D. Jenkins, and Ronald J. Quinn. The identification of bioactive natural products by high throughput screening (HTS).In Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010; volume 3, pp.177–203.

Published Abstracts:

Sykes ML, Avery VM, Parisot J, Street I, Baell J, Chatelain E, Ioset J. High-throughput Screening of the WEHI Compound Library Against Human African Trypanosomiasis. XIIth International Congress of Parasitology (ICOPA), Melbourne, Australia, 2010. Abs 559.

Sykes ML and Avery VM. Development and Comparative Analysis of a 384-well Luciferase-Based Viability HTS Assay for Trypanosoma brucei brucei BS427 cells. XIIth International Congress of Parasitology (ICOPA), Melbourne, Australia, 2010. Abs 1691.

Sykes ML and Avery VM. Application of a 384 well Trypanosoma brucei brucei BS 427 whole cell viability assay to the HTS of a natural product marine fractionated library. 57th American Society of Tropical Medicine and Hygiene (ASTMH) New Orleans, USA, 2008. Abs 536.

Sykes ML and Avery VM. Development of an Alamar Blue 384 Well Whole Cell Viability Assay for HTS of T.b.brucei BS 427 Cells. 57th American Society of Tropical Medicine and Hygiene (ASTMH), New Orleans, USA, 2008. Abs 163.

Longden J, Duffy S, Fechner GA and Avery VM. A novel high throughput imaging assay to screen for natural product compounds with anti-malarial activity. International Journal for Parasitology 2008 Jan1; 38: S62-S62 Suppl. 1.

Fernandez LS. Feng Y, Jobling MF, Andrews KT, Quinn RJ and Avery VM. Isolation of natural product anti-malarial compounds from tropical Queensland and Papua New Guinean plants. International Journal for Parasitology 2008 Jan1; 38: S88-S89 Suppl. 1. Meeting Abstract: P195.